Cu-Catalyzed Aromatic Metamorphosis of 3-Aminoindazoles
Submitted by Jun Zhu on Thu, 09/12/2019 - 08:54
Yao Zhou, Lu Lin, Ya Wang, Jun Zhu and Qiuling Song
We present a novel Cu-catalyzed aromatic metamorphosis of 3-aminoindazoles via oxidative cleavage of two C–N bonds of 3-aminoindazoles. This unprecedented reactivity of 3-aminoindazoles allows one to forge diverse nitrile-containing triphenylenes in decent yields via generation of the cyano group in situ. The current study reveals that 3-aminoindazoles could be harnessed as radical precursors via oxidative denitrogenation, the reaction mechanism of which was supported by density functional theory calculations.